GABAB Receptor Activation Inhibits Neuronal Excitability and Spatial Learning in the Entorhinal Cortex by Activating TREK-2 K+ Channels

MOL 34389 1 Serotonin Inhibits Neuronal Excitability by Activating Two - pore Domain K + Channels in the Entorhinal Cortex

Cholecystokinin facilitates neuronal excitability in the entorhinal cortex via activation of TRPC-like channels.

Cholecystokinin (CCK) is one of the most abundant neuropeptides in the brain, where it interacts with two G protein-coupled receptors (CCK-1 and CCK-2). Activation of both CCK receptors increases the activity of PLC, resulting in increases in intracellular calcium ion (Ca(2+)) release and activation of PKC. Whereas high density of CCK receptors has been detected in the superficial layers of the...

Serotonin inhibits neuronal excitability by activating two-pore domain k+ channels in the entorhinal cortex.

The entorhinal cortex (EC) is regarded as the gateway to the hippocampus; the superficial layers (layers I-III) of the EC convey the cortical input projections to the hippocampus, whereas deep layers of the EC relay hippocampal output projections back to the superficial layers of the EC or to other cortical regions. The superficial layers of the EC receive strong serotonergic projections from t...

Pathogenic potential of antibodies to the GABAB receptor

GABAB receptor (GABABR) autoantibodies have been detected in the serum of immunotherapy-responsive patients with autoimmune encephalitis. This study aimed to investigate the effect of immunoglobulin G (IgG) from a patient with GABABR antibodies on primary neuronal cultures and acute slices of entorhinal cortex. Primary hippocampal neuronal cultures were incubated with serum immunoglobulin from ...

KCa2 channels transiently downregulated during spatial learning and memory in rats.

Small-conductance calcium-activated potassium channels (K(Ca)2) are essential components involved in the modulation of neuronal excitability, underlying learning and memory. Recent evidence suggests that K(Ca)2 channel activity reduces synaptic transmission in a postsynaptic NMDA receptor-dependent manner and is modulated by long-term potentiation. We used radioactive in situ hybridization and ...